ModelBrick 4: AKAP7 binds PLB
Rigatti, M., Le, A.V., Gerber, C., Moraru, I.I. and Dodge-Kafka, K.L., 2015. Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Cellular signalling, 27(9), pp.1807-1815.
This brick describes two ways of forming the complex AKAP_pPLB. Where: a) PLB (phospholamban) phosphorylation can be induced by active PKA after binding AKAP or b) previously phosphorylated PLB binds AKAP.
|Vcell: reaction diagram||Vcell: simulation||SBGN Visualization|
|VCell curated model||CM_PM26027516_MB4.vcml||Designed with VCell|
|SBML||Exported from VCell|
|GraphML||CM_PM26027516_MB4.graphml||Designed with VANTED (SBGN-ED)|
|SBGN-ML||CM_PM26027516_MB4.sbgn||Exported from VANTED (SBGN-ED)|
Maria Heredia, Michael Blinov