ModelBrick 4: AKAP7 binds PLB


Rigatti, M., Le, A.V., Gerber, C., Moraru, I.I. and Dodge-Kafka, K.L., 2015. Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Cellular signalling, 27(9), pp.1807-1815.

PMID:26027516  DOI: 10.1016/j.cellsig.2015.05.016


This brick describes two ways of forming the complex AKAP_pPLB. Where: a) PLB (phospholamban) phosphorylation can be induced by active PKA after binding AKAP or b) previously phosphorylated PLB binds AKAP.


Vcell: reaction diagram Vcell: simulation SBGN Visualization


VCell curated model CM_PM26027516_MB4.vcml Designed with VCell
SBML Exported from VCell
GraphML CM_PM26027516_MB4.graphml Designed with VANTED (SBGN-ED)
SBGN-ML CM_PM26027516_MB4.sbgn Exported from VANTED (SBGN-ED)


Maria Heredia, Michael Blinov