ModelBrick 3: PKA activation


Rigatti, M., Le, A.V., Gerber, C., Moraru, I.I. and Dodge-Kafka, K.L., 2015. Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Cellular signalling, 27(9), pp.1807-1815.

PMID:26027516  DOI: 10.1016/j.cellsig.2015.05.016


This Brick describes the activation of PKA. PKA is a tetramer conformed by two catalytic subunits and two regulatory subunits. The model proposes the activation of the catalytic subunits and allows the regulatory subunits to bind cAMP forming PKA2reg_cAMP(two regulatory subunits binding cAMP) to be later removed from the complex by PDE.


Vcell: reaction diagram VCell: simulation SBGN visualization


VCell curated model CM_PM26027516_MB3.vcml Designed with VCell
SBML Exported from VCell
GraphML CM_PM26027516_MB3.graphml Designed with VANTED (SBGN-ED)
SBGN-ML CM_PM26027516_MB3.sbgn Exported from VANTED (SBGN-ED)


Maria Heredia, Michael Blinov