ModelBrick 3: PKA activation
Rigatti, M., Le, A.V., Gerber, C., Moraru, I.I. and Dodge-Kafka, K.L., 2015. Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Cellular signalling, 27(9), pp.1807-1815.
This Brick describes the activation of PKA. PKA is a tetramer conformed by two catalytic subunits and two regulatory subunits. The model proposes the activation of the catalytic subunits and allows the regulatory subunits to bind cAMP forming PKA2reg_cAMP(two regulatory subunits binding cAMP) to be later removed from the complex by PDE.
|Vcell: reaction diagram||VCell: simulation||SBGN visualization|
|VCell curated model||CM_PM26027516_MB3.vcml||Designed with VCell|
|SBML||Exported from VCell|
|GraphML||CM_PM26027516_MB3.graphml||Designed with VANTED (SBGN-ED)|
|SBGN-ML||CM_PM26027516_MB3.sbgn||Exported from VANTED (SBGN-ED)|
Maria Heredia, Michael Blinov