Stites, E. C., Aziz, M., Creamer, M. S., Von Hoff, D. D., Posner, R. G., & Hlavacek, W. S. (2015).
Use of mechanistic models to integrate and analyze multiple proteomic datasets.
Biophysical journal, 108(7), 1819-1829.

PMID:25863072  DOI: 10.1016/j.bpj.2015.02.030


This model describes the binding and phosphorylation of EGFR by many different proteins which can bind to six different receptors. In this ModelBrick, the binding of proteins to the 998 receptor is described.

The curated model

VCell: reaction diagram VCell: reaction diagram


VCell curated model CM_PM25863072_MB_Y998.vcml Designed with VCell
BNGL CM_PM25863072_MB_Y998.bngl Exported from VCell


Bushrah Khan, Riley Steinberg, Michael Blinov