Curated VCell Model: Binding & Phosphorylation of EGFR


Stites, E. C., Aziz, M., Creamer, M. S., Von Hoff, D. D., Posner, R. G., & Hlavacek, W. S. (2015).
Use of mechanistic models to integrate and analyze multiple proteomic datasets.
Biophysical journal, 108(7), 1819-1829.

PMID:25863072  DOI: 10.1016/j.bpj.2015.02.030


This model describes the binding and phosphorylation of EGFR by many different proteins which can bind to six different receptors. A complete description can be found in the paper linked at the publication section. This completed and curated model has been broken into the six ModelBricks listed under EGFR Rule-Based ModelBricks.

The curated model

VCell: reaction diagram


  VCell curated model CM_PM25863072.vcml Exported from VCell
  BioNetGen file CM_PM25863072.bngl Exported from VCell


  1. Interactions related to Y998 tyrosine residue
  2. Interactions related to Y1016 tyrosine residue
  3. Interactions related to Y1092 tyrosine residue
  4. Interactions related to Y1110 tyrosine residue
  5. Interactions related to Y1172 tyrosine residue
  6. Interactions related to Y1197 tyrosine residue


Bushrah Khan, Riley Steinberg, Michael Blinov