ModelBrick3: Rho GTPase cycle
Ota, T., Maeda, M., Okamoto, M., & Tatsuka, M. (2015).
Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.
BMC systems biology, 9 (1), 3.
This ModelBrick from the article, “Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs” describes a simplified Rho GTPase cycle, displaying the exchanges between GTP and GDP on Rho GTPase. GDIs inhibit GEF and GAP activities by sequestering GTPase and by interacting with GEFs and GAPs.
| SBGN visualization
(modified from publication)
|VCell ModelBrick||download model (.vcml)||Designed with VCell|
|SBML original||CM_PM25628036_MB3.xml||Modified from publication|
|GraphML||CM_PM25628036_MB3.graphml||Exported from VANTED (SBGN-ED)|
|SBGN-ML||CM_PM25628036_MB3.sbgn||Exported from CellDesigner|
John Albanese, Ann Cowan, Michael Blinov