ModelBrick1: Activation of GEF
Ota, T., Maeda, M., Okamoto, M., & Tatsuka, M. (2015).
Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.
BMC systems biology, 9 (1), 3.
This ModelBrick from the article, “Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs” describes the activation of GEF and the degradation of the activator. GDIs inhibit GEF and GAP activities by sequestering GTPase (kinetic law was adjusted to eliminate effect of GDI on both GEF and GAP).
| SBGN visualization
(modified from publication)
|VCell ModelBrick||download model (.vcml)||Designed with VCell|
|SBML original||CM_PM25628036_MB1.xml||Modified from publication|
|GraphML||CM_PM25628036_MB1.graphml||Exported from VANTED (SBGN-ED)|
|SBGN-ML||CM_PM25628036_MB1.sbgn||Exported from CellDesigner|
John Albanese, Ann Cowan, Michael Blinov