Curated Model: Rho GTPase regulation by RhoGDI/GAP interactions
Ota, T., Maeda, M., Okamoto, M., & Tatsuka, M. (2015).
Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.
BMC systems biology, 9 (1), 3.
This model describes how GEFs and GAPs interact with GDIs in Rho GTPase signaling. GDIs have a negative role in Rho GTPase signaling, as they inhibit GEFs, thereby suppressing overall Rho activity. GDIs also have a positive role, in which they inhibit GAPS under specific conditions, allowing sustained Rho activation.
The curated model
VCell reaction diagram
The model with varying GDI activity
|VCell curated model||CM_PM25628036.vcml||designed with VCell|
|GraphML||CM_PM25628036.graphml||exported from VANTED (SBGN-ED)|
|SBGN-ML||CM_PM25628036.sbgn||exported from CellDesigner|
John Albanese, Ann Cowan, Michael Blinov