PDGF Regulated Activation of Src

Publication

Rangamani, P., Lipshtat, A., Azeloglu, E. U., Calizo, R. C., Hu, M., Ghassemi, S., … & Iyengar, R. (2013).
Decoding information in cell shape.
Cell, 154(6), 1356-1369.

PMID: 24034255   DOI: 10.1016/j.cell.2013.08.026

Description

This model represents the activation of Src kinase, which is stimulated by the growth factor PDGF. Protein tyrosine phosphatase (PTP) catalyzes Src activation, while activated Csk modulates the rate at which Src deactivation takes place.

Images

SBGN visualization VCell: Reaction diagram VCell: Pathway diagram

Downloads

VCell curated model CM_PM24034255.vcml designed with VCell
GraphML CM_PM24034255.graphml exported from VANTED (SBGN-ED)
SBGN-ML CM_PM24034255.sbgn exported from VANTED (SBGN-ED)

Contributors

John Albanese, Michael Blinov