PDGF Regulated Activation of Src


Rangamani, P., Lipshtat, A., Azeloglu, E. U., Calizo, R. C., Hu, M., Ghassemi, S., … & Iyengar, R. (2013).
Decoding information in cell shape.
Cell, 154(6), 1356-1369.

PMID: 24034255   DOI: 10.1016/j.cell.2013.08.026


This model represents the activation of Src kinase, which is stimulated by the growth factor PDGF. Protein tyrosine phosphatase (PTP) catalyzes Src activation, while activated Csk modulates the rate at which Src deactivation takes place.


SBGN visualization VCell: Reaction diagram VCell: Pathway diagram


VCell curated model CM_PM24034255.vcml designed with VCell
GraphML CM_PM24034255.graphml exported from VANTED (SBGN-ED)
SBGN-ML CM_PM24034255.sbgn exported from VANTED (SBGN-ED)


John Albanese, Michael Blinov