ModelBrick 2: Cut-out Switch Rab7 activation
Del Conte-Zerial, P., Brusch, L., Rink, J., Collinet, C., Kalaidzidis, Y., Zerial, M., & Deutsch, A. (2008). Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Molecular Systems Biology, 4.
This ModelBrick from the publication “Membrane identity and GTPase cascades regulated by toggle and cut-out switches” describes Rab activation and hydrolysis. According to this model, Rab5 activates Rab7 until Rab7 reaches a threshold upon which it inactivates Rab5 through a negative feedback loop.
|Vcell: Simulation||SBGN visualization|
|VCell curated model||download model (.vcml)||Designed with VCell|
|SBML||Exported from VCell|
|GraphML||CM_PM18628746_MB2.graphml||Exported from VANTED (SBGN-ED)|
|SBGN-ML||CM_PM18628746_MB2.sbgn||Exported from VANTED (SBGN-ED)|
Maria Heredia, Michael Blinov