ModelBrick 2: Cut-out Switch Rab7 activation

Publication

Del Conte-Zerial, P., Brusch, L., Rink, J., Collinet, C., Kalaidzidis, Y., Zerial, M., & Deutsch, A. (2008). Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Molecular Systems Biology, 4.

PMID:18628746  DOI: 10.1038/msb.2008.45  BioModels: BIOMD0000000174

Description

This ModelBrick from the publication “Membrane identity and GTPase cascades regulated by toggle and cut-out switches” describes Rab activation and hydrolysis. According to this model, Rab5 activates Rab7 until Rab7 reaches a threshold upon which it inactivates Rab5 through a negative feedback loop.

Reaction Diagram

Images

Vcell: Simulation SBGN visualization

Downloads

VCell curated model download model (.vcml) Designed with VCell
SBML Exported from VCell
GraphML CM_PM18628746_MB2.graphml Exported from VANTED (SBGN-ED)
SBGN-ML CM_PM18628746_MB2.sbgn Exported from VANTED (SBGN-ED)

Contributors

Maria Heredia, Michael Blinov