Curated Model: Cut-out Switch, Rab5 to Rab7 convertion


Del Conte-Zerial, P., Brusch, L., Rink, J., Collinet, C., Kalaidzidis, Y., Zerial, M., & Deutsch, A. (2008). Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Molecular Systems Biology, 4.

PMID:18628746  DOI: 10.1038/msb.2008.45  BioModels: BIOMD0000000174


This model describes the convertion of Rab5 to Rab7 in the context of conversion of early endosomes into late endosomes. The VCML executable model correspond to Model #2 named “Cut-out Switch” in Del Conte, P. publication which includes cooperativity of auto-activation loops (marked in red in the SBGN visualization).


Vcell: reaction diagram SBGN visualization
Vcell Simulation Publication Figure 4D. Numeric Representation of Model 2


VCell curated model CM_PM18628746.vcml Designed with VCell
SBML BIOMD0000000174.xml Exported from BioModels database
GraphML CM_PM18628746.graphml Exported from VANTED (SBGN-ED)
SBGN-ML CM_PM18628746.sbgn Exported from VANTED (SBGN-ED)


  1. Rab5 activation
  2. Rab7 activation


Maria Heredia, Michael Blinov