Curated Model: Cut-out Switch, Rab5 to Rab7 convertion
Del Conte-Zerial, P., Brusch, L., Rink, J., Collinet, C., Kalaidzidis, Y., Zerial, M., & Deutsch, A. (2008). Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Molecular Systems Biology, 4.
This model describes the convertion of Rab5 to Rab7 in the context of conversion of early endosomes into late endosomes. The VCML executable model correspond to Model #2 named “Cut-out Switch” in Del Conte, P. publication which includes cooperativity of auto-activation loops (marked in red in the SBGN visualization).
|Vcell: reaction diagram||SBGN visualization|
|Vcell Simulation||Publication Figure 4D. Numeric Representation of Model 2|
|VCell curated model||CM_PM18628746.vcml||Designed with VCell|
|SBML||BIOMD0000000174.xml||Exported from BioModels database|
|GraphML||CM_PM18628746.graphml||Exported from VANTED (SBGN-ED)|
|SBGN-ML||CM_PM18628746.sbgn||Exported from VANTED (SBGN-ED)|
Maria Heredia, Michael Blinov