Curated Model: Minimal model for mitotic oscillator involving cyclin and cdc2 kinase

Publication

Goldbeter, A. (1991).
A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.
Proceedings of the National Academy of Sciences, 88(20), 9107-9111.

PMID: 1833774  DOI: 10.1073/pnas.88.20.9107  BioModel: BIOMD0000000003

Description

This model is based on the cascade of post-translational modification that modulates the activity of cdc2 kinase during the cell cycle. The model pertains to the situation encountered in early amphibian embryos, where the accumulation of cyclin suffices to trigger the onset of mitosis.

Images

SBGN visualization VCell: Reaction diagram

VCell: Simulation Publication: Simulation
Figure 3

Downloads

  VCell curated model CM_PM1833774.vcml Designed with VCell
  SBML BIOMD0000000003.xml Exported from BioModels database
  GraphML CM_PM1833774.graphml Designed with VANTED (SBGN-ED)
  SBGN-ML CM_PM1833774.sbgn Exported from VANTED (SBGN-ED)

Contributors

John Albanese, Michael Blinov