Curated Model: Minimal model for mitotic oscillator involving cyclin and cdc2 kinase


Goldbeter, A. (1991).
A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.
Proceedings of the National Academy of Sciences, 88(20), 9107-9111.

PMID: 1833774  DOI: 10.1073/pnas.88.20.9107  BioModel: BIOMD0000000003


This model is based on the cascade of post-translational modification that modulates the activity of cdc2 kinase during the cell cycle. The model pertains to the situation encountered in early amphibian embryos, where the accumulation of cyclin suffices to trigger the onset of mitosis.


SBGN visualization VCell: Reaction diagram

VCell: Simulation Publication: Simulation
Figure 3


  VCell curated model CM_PM1833774.vcml Designed with VCell
  SBML BIOMD0000000003.xml Exported from BioModels database
  GraphML CM_PM1833774.graphml Designed with VANTED (SBGN-ED)
  SBGN-ML CM_PM1833774.sbgn Exported from VANTED (SBGN-ED)


John Albanese, Michael Blinov