Curated Model: Circaidan clock control by short and long FRQ protein
Akman, O. E., Locke, J. C., Tang, S., Carré, I., Millar, A. J., & Rand, D. A. (2008).
Isoform switching facilitates period control in the Neurospora crassa circadian clock.
Molecular Systems Biology, 4(1).
This model of the Neurospora circadian clock illustrates how the parallel, temperature-dependent FRQ feedback loops can give rise to temperature compensation and period control through isoform switching. This model is an extension of an existing model by Leloup et al. (PMID: 10643740). The model involves only the frq gene and demonstrates that the isoform switching mechanism is not specific to a particular set of equations.
|VCell: Reaction diagram|
Figure 5 (Supplementary information)
|VCell curated model||CM_PM18277380.vcml||Designed with VCell|
|SBML||BIOMD0000000295.xml||Exported from BioModels database|
John Albanese, Michael Blinov