Curated Model: Circaidan clock control by short and long FRQ protein


Akman, O. E., Locke, J. C., Tang, S., Carré, I., Millar, A. J., & Rand, D. A. (2008).
Isoform switching facilitates period control in the Neurospora crassa circadian clock.
Molecular Systems Biology, 4(1).

PMID: 18277380  DOI: 10.1038/msb.2008.5  BioModel: BIOMD0000000295


This model of the Neurospora circadian clock illustrates how the parallel, temperature-dependent FRQ feedback loops can give rise to temperature compensation and period control through isoform switching. This model is an extension of an existing model by Leloup et al. (PMID: 10643740). The model involves only the frq gene and demonstrates that the isoform switching mechanism is not specific to a particular set of equations.


VCell: Reaction diagram

VCell: Simulation
frq mRNA
VCell: Simulation
Publication: Simulation
Figure 5 (Supplementary information)


  VCell curated model CM_PM18277380.vcml Designed with VCell
  SBML BIOMD0000000295.xml Exported from BioModels database


  1. Transcription of frq
  2. Translation of FRQ


John Albanese, Michael Blinov