Curated Model: Methionine and Threonine Pathways: The Branch - Point


Curien, G., Ravanel, S., & Dumas, R. (2003). A kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana. European Journal Of Biochemistry, 270(23).
PMID:14622248   DOI: 10.1046/j.1432-1033.2003.03851.x  BioModels: BIOMD0000000068


This Model proposed the Branching of Methionine and Threonine Biosynthesis Pathways in Arabidospsis thaliana, where Cystathionine gamma-synthase (CGS) and Threonine Synthase (TS) compete kinetically for phosphohomoserine. S-adenosylmethionine is the substrat for CGS which is responsible for the synthesis of cystathionine - precursor of methionine- and TS produces threonine.


Vcell: reaction diagram SBGN visualization
Vcell: Simulation
Experimental parameters were set at the moment of simulation (250uM Cistheine and 0.3uM/s of Phosphohoserine flux)
Publication fig. 2B
Ligand concentration dependent plot based on Vcell simulation
Simulation run for 10000s in VCell, and the last output flux for Cisthationine and Threonine were used to plot against adenosylmethionine concentration (range 0-100uM). Plot was made using Excel.
Publication fig. 3C


VCell curated model CM_PM14622248.vcml Designed with VCell
XML BIOMD0000000068.xml Exported from BioModels database
GraphML CM_PM14622248.graphml Designed with VANTED (SBGN-ED)
SBGN-ML CM_PM14622248.sbgn Exported from VANTED (SBGN-ED)
XLS Simulation_results.xls Ploted in Excel


Maria Heredia, Ann Cowan, Michael Blinov