Negative Feedback: Oscillator
Tyson, J. J., Chen, K. C., & Novak, B. (2003).
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Current opinion in cell biology, 15(2), 221-231.
This ModelBrick from the article, “Sniffers, buzzers, toggles and blinkers…” describes negative feedback (X activates Y through phosphorylation, phospho-Y in turn activates R through phosphorylation, with phospho-R degrading X) creating an oscillatory response.
|VCell ModelBrick||download model (.vcml)||Designed with VCell|
Michael Blinov, John Albanese