Negative Feedback: Homeostasis


Tyson, J. J., Chen, K. C., & Novak, B. (2003).
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Current opinion in cell biology, 15(2), 221-231.

PMID: 12648679   DOI: 10.1016/S0955-0674(03)00017-6


This ModelBrick from the article, “Sniffers, buzzers, toggles and blinkers…” describes negative feedback in which the response counteracts stimulus effects. The response element, R, inhibits the enzyme catalyzing its synthesis (E); hence, the rate of production of R is a sigmoidal decreasing function of R. The steady state concentration of R is confines to a narrow window for a broad range of signal strengths, because the supply of R adjusts to its demand. This type of regulation, commonly employed in biosynthetic pathways, is called homeostasis.

Reaction Diagram



  VCell ModelBrick download model (.vcml) Designed with VCell


Michael Blinov, John Albanese