Activator-Inhibitor Oscillator


Tyson, J. J., Chen, K. C., & Novak, B. (2003).
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Current opinion in cell biology, 15(2), 221-231.

PMID: 12648679   DOI: 10.1016/S0955-0674(03)00017-6


This ModelBrick from the article, “Sniffers, buzzers, toggles and blinkers…” describes a system containing both positive and negative feedback, resulting in oscillations. The response element (R) is created in an autocatalytic process, and then it promotes the production of an inhibitor, X, which speeds up R removal. First, R builds up, then comes X to force R back down, then X disappears and R can rise again.

Reaction Diagram



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Michael Blinov, John Albanese