Perfectly Adapted Signal-Response
Tyson, J. J., Chen, K. C., & Novak, B. (2003).
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Current opinion in cell biology, 15(2), 221-231.
This ModelBrick from the article, “Sniffers, buzzers, toggles and blinkers…” describes a simple linear response element supplemented with a second signaling pathway (through species X), creating a response mechanism that exhibits perfect adaptation to the signal. Although the signaling pathway exhibits a transient response to changes in signal strength, its steady-state response is independent of the signal strength (S).
|SBGN visualization||VCell: Simulation|
|VCell ModelBrick||download model (.vcml)||Designed with VCell|
|SBML||CM_PM12648679_MB3.xml||Exported from VCell|
|GraphML||CM_PM12648679_MB3.graphml||Designed with yED|
|SBGN-ML||CM_PM25628036_MB3.sbgn||Converted with ySBGN|