Perfectly Adapted Signal-Response


Tyson, J. J., Chen, K. C., & Novak, B. (2003).
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Current opinion in cell biology, 15(2), 221-231.

PMID: 12648679   DOI: 10.1016/S0955-0674(03)00017-6


This ModelBrick from the article, “Sniffers, buzzers, toggles and blinkers…” describes a simple linear response element supplemented with a second signaling pathway (through species X), creating a response mechanism that exhibits perfect adaptation to the signal. Although the signaling pathway exhibits a transient response to changes in signal strength, its steady-state response is independent of the signal strength (S).

Reaction Diagram


SBGN visualization VCell: Simulation


  VCell ModelBrick download model (.vcml) Designed with VCell
  SBML CM_PM12648679_MB3.xml Exported from VCell
  GraphML CM_PM12648679_MB3.graphml Designed with yED
  SBGN-ML CM_PM25628036_MB3.sbgn Converted with ySBGN


Michael Blinov