ModelBrick 3: TetR represses cI’s transcription and translation


Elowitz, M., & Leibler, S. (2000). A synthetic oscillatory network of transcriptional regulators. Nature, 403(6767), 335-338.
PMID:10659856  DOI: 10.1038/35002125


This ModelBrick describes changes in the concentration of protein cI under the transcriptional repressor activity of TetR. The model represent the activity of the protein repressor tetR over the transcription and tranlation of cI, and compared to the other two related ModelBricks the mRNA transcription and degradation of the repressor protein is introduced. The initial concentration of cI protein was set at 100 molecules/um3, and we kept other species’s concentrations as in the original model.


Vcell: reaction diagram Vcell: Simulation SBGN visualization


VCell curated model CM_PM10659856_MB3.vcml Designed with VCell
SBML Exported from VCell
GraphML CM_PM10659856_MB3.graphml Exported from VANTED (SBGN-ED)
SBGN-ML CM_PM10659856_MB3.sbgn Exported from VANTED (SBGN-ED)