ModelBrick 2: LacI represses TetR transcription and translation


Elowitz, M., & Leibler, S. (2000). A synthetic oscillatory network of transcriptional regulators. Nature, 403(6767), 335-338.
PMID:10659856  DOI: 10.1038/35002125


This ModelBrick describes changes in the concentration of protein TetR under the transcriptional repressor activity of LacI. The simulation consider a change in the species concentration compare to original Model to better represent the activity of the protein repressor lacI over the transcription, and translation of TetR. The initial concentration of the repressor protein was set at 150 molecules/um3, and we kept the initial concentration of LacI mRNA and LacI protein at 20 and 0 molecules/um3 as in the original model.


Vcell: reaction diagram Vcell: Simulation SBGN visualization


VCell curated model CM_PM10659856_MB2.vcml Designed with VCell
SBML Exported from VCell
GraphML CM_PM10659856_MB2.graphml Exported from VANTED (SBGN-ED)
SBGN-ML CM_PM10659856_MB2.sbgn Exported from VANTED (SBGN-ED)